Hemodinámica en el síndrome de Down / Haemodynamics in Down syndrome

No disponible

Réplica a «Tratamiento de la hiperuricemia asintomática» / Reply to «Treatment of asymptomatic hyperuricaemia»

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La ecografía en el diagnóstico de la hiperuricemia asintomática y la gota / Ultrasound in the diagnosis of asymptomatic hyperuricaemia and gout

El aumento de la concentración sérica de uratos (hiperuricemia, mayor o igual a 7,0mg/dL) ocasiona cristales que promueven inflamación y lesión articular. La ecografía puede poner de manifiesto estos depósitos de urato. Su presencia obliga a considerar que un paciente con hiperuricemia en realidad padece gota asintomática, y que un enfermo con gota sin tofos subcutáneos puede tener gota tofácea. La información que ofrece la ecografía (signo del «doble contorno» y de concreciones hiperecogénicas simulando nubes) posibilita una clasificación de la hiperuricemia y de la gota más precisas. Además, esta información puede dar lugar a modificaciones relevantes en cuanto al proceder diagnóstico y terapéutico en los enfermos con hiperuricemia y gota (AU)

The increase in serum urate concentrations (hyperuricaemia, ≥7.0mg/dL) creates crystals, which promote inflammation and joint lesions. Ultrasonography can reveal these urate deposits. The presence of crystals suggests that a patient with hyperuricaemia is actually experiencing asymptomatic gout, and that a patient with gout without subcutaneous tophi could experience tophaceous gout. The information offered by ultrasound (double contour sign and hyperechoic concretions mimicking clouds) enables a more specific classification of hyperuricaemia and gout. Additionally, this information can lead to relevant changes in terms of the diagnosis and therapeutic approach for patients with hyperuricaemia and gout (AU)

Ultrasound in the diagnosis of asymptomatic hyperuricaemia and gout. / La ecografía en el diagnóstico de la hiperuricemia asintomática y la gota.

The increase in serum urate concentrations (hyperuricaemia, ≥7.0mg/dL) creates crystals, which promote inflammation and joint lesions. Ultrasonography can reveal these urate deposits. The presence of crystals suggests that a patient with hyperuricaemia is actually experiencing asymptomatic gout, and that a patient with gout without subcutaneous tophi could experience tophaceous gout. The information offered by ultrasound (double contour sign and hyperechoic concretions mimicking clouds) enables a more specific classification of hyperuricaemia and gout. Additionally, this information can lead to relevant changes in terms of the diagnosis and therapeutic approach for patients with hyperuricaemia and gout.

Role of COX-2-derived PGE2 on vascular stiffness and function in hypertension.

BACKGROUND AND PURPOSE: Prostanoids derived from COX-2 and EP receptors are involved in vascular remodelling in different cardiovascular pathologies. This study evaluates the contribution of COX-2 and EP1 receptors to vascular remodelling and function in hypertension. EXPERIMENTAL APPROACH: Spontaneously hypertensive rats (SHR) and angiotensin II (AngII)-infused (1.44 mg · kg(-1) · day(-1), 2 weeks) mice were treated with the COX-2 inhibitor celecoxib (25 mg · kg(-1) · day(-1) i.p) or with the EP1 receptor antagonist SC19220 (10 mg · kg(-1) · day(-1) i.p.). COX-2(-/-) mice with or without AngII infusion were also used. KEY RESULTS: Celecoxib and SC19220 treatment did not modify the altered lumen diameter and wall : lumen ratio in mesenteric resistance arteries from SHR-infused and/or AngII-infused animals. However, both treatments and COX-2 deficiency decreased the augmented vascular stiffness in vessels from hypertensive animals. This was accompanied by diminished vascular collagen deposition, normalization of altered elastin structure and decreased connective tissue growth factor and plasminogen activator inhibitor-1 gene expression. COX-2 deficiency and SC19220 treatment diminished the increased vasoconstrictor responses and endothelial dysfunction induced by AngII infusion. Hypertensive animals showed increased mPGES-1 expression and PGE2 production in vascular tissue, normalized by celecoxib. Celecoxib treatment also decreased AngII-induced macrophage infiltration and TNF-α expression. Macrophage conditioned media (MCM) increased COX-2 and collagen type I expression in vascular smooth muscle cells; the latter was reduced by celecoxib treatment. CONCLUSIONS AND IMPLICATIONS: COX-2 and EP1 receptors participate in the increased extracellular matrix deposition and vascular stiffness, the impaired vascular function and inflammation in hypertension. Targeting PGE2 receptors might have benefits in hypertension-associated vascular damage.

Si le llaman la atención los resultados de un artículo, léalo completo, no se fíe solo del resumen / If the results of an article are noteworthy, read the entire article; do not rely on the abstract alone

Es habitual que los clínicos actualicen sus conocimientos con la lectura de artículos a través de Internet. El fácil acceso al resumen de los artículos y la falta de tiempo para acceder a otros tipos de fuentes de información hace que exista el riesgo de que, en ocasiones, se puedan tomar decisiones terapéuticas o diagnósticas tras la sola lectura de los resúmenes. Ocasionalmente, sin embargo, en los resúmenes de artículos de ensayos clínicos que no han obtenido diferencias estadísticamente significativas en la variable principal de evaluación, se informa de otros resultados positivos, por ejemplo, de una variable secundaria o en un subgrupo de participantes. En el artículo, no obstante, se informa correctamente de todos los resultados obtenidos, incluso de los de la variable principal de evaluación. En el resumen, la información de seguridad del tratamiento experimental suele ser deficiente. Se debe leer el artículo completo si se va a tomar una decisión clínica (AU)

Clinicians typically update their knowledge by reading articles on the Internet. Easy access to the articles’ abstracts and a lack of time to access other information sources creates a risk that therapeutic or diagnostic decisions will be made after reading just the abstracts. Occasionally, however, the abstracts of articles from clinical trials that have not obtained statistically significant differences in the primary study endpoint have reported other positive results, for example, of a secondary endpoint or a subgroup analysis. The article, however, correctly reports all results, including those of the primary endpoint. In the abstract, the safety information of the experimental treatment is usually deficient. The whole article should be read if a clinical decision is to be made (AU)

If the results of an article are noteworthy, read the entire article; do not rely on the abstract alone. / Si le llaman la atención los resultados de un artículo, léalo completo, no se fíe solo del resumen.

Clinicians typically update their knowledge by reading articles on the Internet. Easy access to the articles' abstracts and a lack of time to access other information sources creates a risk that therapeutic or diagnostic decisions will be made after reading just the abstracts. Occasionally, however, the abstracts of articles from clinical trials that have not obtained statistically significant differences in the primary study endpoint have reported other positive results, for example, of a secondary endpoint or a subgroup analysis. The article, however, correctly reports all results, including those of the primary endpoint. In the abstract, the safety information of the experimental treatment is usually deficient. The whole article should be read if a clinical decision is to be made.

Informe de los Editores, 2014 / Report of the Editors, 2014

Los editores de Revista Clínica Española(Rev Clin Esp) informan de su actuación editorial durante los últimos 12 meses: a) Objetivos y logros en 2014; b) Actividad editorial, 2014 y c) Factor impacto 2013. Durante el año 2014 se han alcanzado los 5 objetivos trazados. Hemos publicado los 9 números programados en el año con un 103% de artículos publicados sobre los previstos en las secciones fijas habituales. Destacamos la publicación de 29 editoriales, de los cuales 21 están firmados por autores extranjeros de gran prestigio. Entre el 1 de enero y el 30 de septiembre de 2014 hemos recibido 421 manuscritos (46,8 manuscritos/mes), cifra algo inferior a la del año 2013 (50,9 manuscritos/mes). De 404 manuscritos con proceso editorial concluido hemos aceptado un 32,3% (originales, 22,4%). Hemos cursado 315 solicitudes de revisión a 240 revisores, y hemos recibido el 53,3% de las revisiones solicitadas en menos de 2 semanas (10,4 días). El tiempo medio para adoptar una decisión editorial definitiva para todos los manuscritos («aceptado» o «rechazado») ha sido de 18,3 días (más de la mitad que en 2009). Para los «originales» esta cifra ha descendido desde 56,6 días en 2009 a 26,6 días en 2014. Desde la recepción de un manuscrito hasta su publicación on-line el tiempo medio ha sido de 103 días en 2014. En el año 2014, los grupos de trabajo de la Fundación Española de Medicina Interna (FEMI) han publicado 11 manuscritos. En julio de 2014 conocimos que el Journal Citation Reports había otorgado a Rev Clin Esp un Factor Impacto de 1.314 (año 2013). Este Factor Impacto sin autocita es de 0,705 (en el año 2009, el Factor Impacto global fue de 0,584). Con el adiós al comité editorial de Rev Clin Esp damos la bienvenida al nuevo equipo editorial y damos las gracias sinceras a la sucesivas Juntas Directivas de la SEMI, a los compañeros, personal de la revista, revisores, lectores y autores, que desde el año 2009 han confiado en nuestra gestión editorial (AU)

The editors of Revista Clínica Española(Rev Clin Esp) inform on their editorial activity during the last 12 months: (a) Objectives and attainments in 2014, (b) Editorial activity, 2014, and (c) 2013 impact factor. In 2014 we achieved the 5 planned objectives. We have published the 9 programmed issues and 103% of the planned papers according to the usual fixed sections. We emphasize the publication of 29 editorials, 21 of which are signed by prestigious foreign authors. From the first January to the 30th September 2014 we received 421 manuscripts (46.8 manuscripts per month), a slight lower figure to that obtained in 2013 (50.9 manuscripts per month). The acceptance rate of the 404 manuscripts whose editorial process has been concluded was 32.3% (originals, 22.4%). We asked for 315 revisions to 240 reviewers and we received 53.3% revisions in less than two weeks (10.4 days). The mean time to adopt an editorial decision for all manuscripts («accepted»/«rejected») has been 18,3 (less than half than in 2009). For «originals» this figure has dropped from 56,6 days in 2009 to 26.6 days in 2014. The mean time elapsed from manuscript reception to its on-line publication was 103 days. In 2014 the collaboration with the working groups from the Internal Medicine Spanish Foundation (FEMI) has reported 11 published manuscripts. In July 2014 we were informed that the Journal Citation Reports gave Rev Clin Esp an Impact Factor of 1,314 (year 2013). This Impact Factor without self-citations would have been 0.705 (in 2009 the global impact factor was 0,584). With the Editorial Committee farewell we welcome the new editorial team and we sincerely thank the SEMI Steering Committee, our colleagues, journal officers, reviewers, readers and authors that since 2009 have trusted on our editorial work (AU)

Report of the editors, 2014. / Informe de los Editores, 2014.

The editors of Revista Clínica Española(Rev Clin Esp) inform on their editorial activity during the last 12 months: (a) Objectives and attainments in 2014, (b) Editorial activity, 2014, and (c) 2013 impact factor. In 2014 we achieved the 5 planned objectives. We have published the 9 programmed issues and 103% of the planned papers according to the usual fixed sections. We emphasize the publication of 29 editorials, 21 of which are signed by prestigious foreign authors. From the first January to the 30th September 2014 we received 421 manuscripts (46.8 manuscripts per month), a slight lower figure to that obtained in 2013 (50.9 manuscripts per month). The acceptance rate of the 404 manuscripts whose editorial process has been concluded was 32.3% (originals, 22.4%). We asked for 315 revisions to 240 reviewers and we received 53.3% revisions in less than two weeks (10.4 days). The mean time to adopt an editorial decision for all manuscripts («accepted¼/«rejected¼) has been 18,3 (less than half than in 2009). For «originals¼ this figure has dropped from 56,6 days in 2009 to 26.6 days in 2014. The mean time elapsed from manuscript reception to its on-line publication was 103 days. In 2014 the collaboration with the working groups from the Internal Medicine Spanish Foundation (FEMI) has reported 11 published manuscripts. In July 2014 we were informed that the Journal Citation Reports gave Rev Clin Esp an Impact Factor of 1,314 (year 2013). This Impact Factor without self-citations would have been 0.705 (in 2009 the global impact factor was 0,584). With the Editorial Committee farewell we welcome the new editorial team and we sincerely thank the SEMI Steering Committee, our colleagues, journal officers, reviewers, readers and authors that since 2009 have trusted on our editorial work.

[Report of the editors, 2013]. / Informe de los editores, 2013.

The editors of Revista Clínica Española(Rev Clin Esp) inform on their editorial activity during the last 12 months: (a) objectives and attainments, (b) editorial activity, and (c) objectives for 2014. In 2013 the most relevant modification concerning the editorial activity has been the translation into English of the 5 manuscripts with abstract contained in each issue (http://www.revclinesp.es/). From the first January to the 30th September 2013 we received 458 manuscripts (50.9 manuscripts per month), a similar figure to that obtained in 2012 (51.1 manuscripts per month). The acceptance rate of the 443 manuscripts whose editorial process has been concluded was 23.7% (originals, 11.8%). We asked for 253 revisions to 186 reviewers and we received 74.4% revisions in less than 2 weeks (10.9 days). The mean time to adopt an editorial decision for all manuscripts («accepted¼/«rejected¼) has been 20,3 (half than in 2009). For «originals¼ this figure has dropped from 56.6 days in 2009 to 22.5 days in 2013. The mean time elapsed from manuscript reception to its on-line publication was 94.8 days in 2013 (110.5 in 2012 and 155.8 in 2011). In 2013 the collaboration with the working groups from the Internal Medicine Spanish Foundation has reported 17 published manuscripts. In 2013 we were informed that the Journal Citation Reports excluded Rev Clin Esp from its impact factor journal list due to its elevated self-citations. We have taken a number of actions to reduce self-citations and we expect to be a minority in 2014. Some other data concerning the editorial policy are encouraging. In this sense, manuscript citation to Rev Clin Esp published articles has seen a substantial increase from 19% in 2008 to 29% in 2012. We work to achieve the digitalization of Rev Clin Esp from 1940 to 1999 (the journal is already digitalized since 2000). The continuous renewal of the journal sections and the working groups collaboration are necessary elements to make our journal, each day, better.

Informe de los editores, 2012 / Editors’ report, 2012

Los editores de Revista Clínica Española (Rev Clin Esp) informan de su trabajo editorial durante los últimos 12 meses: a) objetivos y consecuciones; b) actividad editorial; y c) objetivos para el año 2013. Durante el año 2012 las modificaciones más relevantes han sido: a) cada manuscrito enviado a los revisores externos ha sido evaluado de forma pormenorizada por el editor responsable, y b) traducción al inglés de los 5 manuscritos con resumen de cada número. Entre el 1 de enero y el 30 de septiembre del 2012 hemos gestionado 457 manuscritos (50 manuscritos/mes), cifra algo superior a la del año 2011 (40,8 manuscritos/mes). Se han aceptado un 27,2% de todos los manuscritos (originales, 13,0%). Hemos cursado 295 solicitudes de revisión a 241 revisores y recibido el 66,1% de las revisiones solicitadas en menos de 2 semanas (tiempo medio de recepción de las revisiones, 11,3 días). El tiempo medio para adoptar una decisión editorial definitiva para todos los manuscritos («aceptado»/«rechazado») ha sido de 23,9 días (31,3 días en 2011; 35,4 días en 2010). Esta cifra ha sido de 29,4 días para los manuscritos originales (9,5 y 12,3 días menos que en 2011 y 2010, respectivamente). El tiempo medio desde la recepción de un manuscrito hasta su publicación on-line ha descendido de 203 días en 2010, a 168 en 2011 y 115 en 2012. En el año 2012, los grupos de trabajo de la Fundación Española de Medicina Interna (FEMI) han publicado 19 manuscritos. Para el año 2013 esperamos que la versión en inglés de Rev Clin Esp sea una realidad, al igual que la digitalización de los contenidos desde 1940 a 1999, pues ya está disponible desde el año 2000. La renovación de las secciones actuales (i.e., conferencia clínica; una imagen para el diagnóstico) pretende, con la colaboración de todos, que nuestra revista sea, cada día, mejor(AU)

The editors of Revista Clínica Española (Rev Clin Esp) inform on their editorial activity during the last 12 months: a) objectives and attainments; b) editorial activity; and c) objectives for 2013. In 2012 the most relevant modifications concerning the editorial activity have been: a) revision by the responsible editor of all manuscripts sent to peer review, and b) translation into English of five manuscripts with abstract of each issue. From the first January to the 30th September 2012 we handled 457 manuscripts (50 manuscripts per month) a figure 22.5% higher than in 2011 (40.8 manuscripts per month). We have accepted 27.2% of all manuscripts (originals, 13.0%). We asked for 295 revisions to 241 reviewers and we have received 66.1% of the revisions asked for in less than two weeks (mean time to receive a revision, 11.3 days). The mean time to adopt an editorial decision for all manuscripts («accept»/«reject») has been 23.9 days (31.3 days in 2011; 35.4 in 2010). This figure has been 29.4 days for the original manuscripts (9.5 and 12.3 days less than in 2011 and 2010, respectively). The mean time taken since a manuscript is received to publication has dropped from 203 days in 2010, 168 in 2011 and 115 in 2012 (less than 3 months). The collaboration with the working groups has reported 19 published manuscripts in 2012. We hope that in 2013 both the English version and the digitalization of Rev Clin Esp from 1940 to 1999 (the journal is already digitalized since 2000) will become a reality. The renewal of the actual sections (i.e., clinical conference, an image for a diagnosis) pretends, with the collaboration of all, to make our journal, each day, better(AU)

Editors' report, 2012.

The editors of Revista Clínica Española (Rev Clin Esp) inform on their editorial activity during the last 12 months: a) objectives and attainments; b) editorial activity; and c) objectives for 2013. In 2012 the most relevant modifications concerning the editorial activity have been: a) revision by the responsible editor of all manuscripts sent to peer review, and b) translation into English of five manuscripts with abstract of each issue. From the first January to the 30th September 2012 we handled 457 manuscripts (50 manuscripts per month) a figure 22.5% higher than in 2011 (40.8 manuscripts per month). We have accepted 27.2% of all manuscripts (originals, 13.0%). We asked for 295 revisions to 241 reviewers and we have received 66.1% of the revisions asked for in less than two weeks (mean time to receive a revision, 11.3 days). The mean time to adopt an editorial decision for all manuscripts («accept¼/«reject¼) has been 23.9 days (31.3 days in 2011; 35.4 in 2010). This figure has been 29.4 days for the original manuscripts (9.5 and 12.3 days less than in 2011 and 2010, respectively). The mean time taken since a manuscript is received to publication has dropped from 203 days in 2010, 168 in 2011 and 115 in 2012 (less than 3 months). The collaboration with the working groups has reported 19 published manuscripts in 2012. We hope that in 2013 both the English version and the digitalization of Rev Clin Esp from 1940 to 1999 (the journal is already digitalized since 2000) will become a reality. The renewal of the actual sections (i.e., clinical conference, an image for a diagnosis) pretends, with the collaboration of all, to make our journal, each day, better.

Informe de los editores, 2011 / Report of the editors, 2011

Los editores de R evista C línica E spañola (Rev Clin Esp) informan de su actuación editorial durante los últimos 12 meses (noviembre 2010 a octubre 2011): a) objetivos y consecuciones durante el año 2011; b) actividad editorial, y c) objetivos para el año 2012. Durante el año 2011 hemos perfeccionado el algoritmo editorial (evaluación por un editor de cada manuscrito enviado a revisores externos y creación de la figura de la «coordinadora editorial»), renovado los dos órganos consultivos («consejo editorial y consejo científico»), implantado la sección «imagen del mes», y se han concedido por primera vez los premios anuales Rev Clin Esp. Entre el 1 de enero y el 31 de octubre de 2011 se han gestionado 422 manuscritos (42,2 manuscritos/mes), cifra algo superior a la del año 2010 (40,4 manuscritos/mes), de los cuales han sido aceptados un 25,6% (originales, 16%). Hemos cursado 343 solicitudes de evaluación a 231 revisores, siendo aceptadas 185 de ellas. El 72% de los revisores enviaron sus comentarios en menos de dos semanas (tiempo medio de recepción de revisiones: 11 días). El tiempo medio para adoptar una decisión editorial definitiva (aceptado o rechazado) ha sido de 26 días. El tiempo medio transcurrido desde la fecha de remisión hasta la de publicación de los originales (números de septiembre, octubre y noviembre) ha pasado de 334 días en el 2010 a 254 en el 2011 (reducción del 24%). La participación de los grupos de trabajo de la Fundación Española de Medicina Interna (FEMI) ha sido próxima a dos manuscritos/número. Para el año 2012 hemos establecido los siguientes objetivos: a) mejorar el proceso de edición; b) traducir al inglés los artículos principales; c) actualizar algunas secciones (p. ej., conferencia clínica); d) incentivar la colaboración de los grupos de trabajo, y e) mejorar la formación médica continuada. R evista C línica E spañola es un foro abierto a la contribución de todos los internistas. A todos nos cabe la responsabilidad de colaborar para que nuestra revista sea, cada día, un poco mejor(AU)

The editors of R evista C línica E spañola (Rev Clin Esp) inform on their editorial activity during the last 12 months (November 2010 to October 2011): (a) Objectives and attainments during 2011, (b) editorial activity, and (c) objectives for 2012. In 2011 we have updated the editorial algorithm (revision by the responsible editor of all manuscripts sent to peer review and incorporated an «editorial coordinator»), we have renovated two advise facilities (editorial and scientific committees), we have created a new section called «monthly e-image», and we have promoted Rev Clin Esp annual prizes. From the first January 2010 to 31st October 2011 we handled 422 manuscripts (42,2 manuscripts per month, higher than the 2010 figure of 40,4 manuscript/month). Overall we have accepted 26% (originals, 16%). We asked for 343 revisions and obtained 231 (67%). Seventy two percent of the reviewers sent their comments in less than two weeks. The mean time taken to accept or reject a given manuscript has been 26 days. The mean time taken since a manuscript is received to publication (october, novembrer and december issues) has dropped from 334 days in 2010 to 254 in 2011 (24% decrease). The collaboration with the working groups has reported about 2 published manuscripts per issue. Our objectives for 2012 are: (a) to improve the editorial process; (b) main article translation into English; (c) improve some sections (i.e. clinical conference); (d) estimulate working groups collaboration; and (e) improve continued medical education. R evista C línica E spañola is an open forum for all internal medicine specialists. We all have the responsibility to make our journal, each day, better(AU)

[Report of the editors, 2011]. / Informe de los editores, 2011.

The editors of Revista Clínica Española (Rev Clin Esp) inform on their editorial activity during the last 12 months (November 2010 to October 2011): (a) Objectives and attainments during 2011, (b) editorial activity, and (c) objectives for 2012. In 2011 we have updated the editorial algorithm (revision by the responsible editor of all manuscripts sent to peer review and incorporated an «editorial coordinator¼), we have renovated two advise facilities (editorial and scientific committees), we have created a new section called «monthly e-image¼, and we have promoted Rev Clin Esp annual prizes. From the first January 2010 to 31(st) October 2011 we handled 422 manuscripts (42,2 manuscripts per month, higher than the 2010 figure of 40,4 manuscript/month). Overall we have accepted 26% (originals, 16%). We asked for 343 revisions and obtained 231 (67%). Seventy two percent of the reviewers sent their comments in less than two weeks. The mean time taken to accept or reject a given manuscript has been 26 days. The mean time taken since a manuscript is received to publication (october, novembrer and december issues) has dropped from 334 days in 2010 to 254 in 2011 (24% decrease). The collaboration with the working groups has reported about 2 published manuscripts per issue. Our objectives for 2012 are: (a) to improve the editorial process; (b) main article translation into English; (c) improve some sections (i.e. clinical conference); (d) estimulate working groups collaboration; and (e) improve continued medical education. Revista Clínica Española is an open forum for all internal medicine specialists. We all have the responsibility to make our journal, each day, better.

[2009 report from the editors]. / Informe de los editores: 2009.

The editors of the Rev Clin Esp present the editorial course of action of the journal over the past year. We have up-dated the design of the journal, its contents (sections) and computerized the editorial process. We processed 467 manuscripts and made an editorial decision on 402 of them between November 2008 and October 2009. A total of 92 manuscripts (23%) were accepted. Fifteen (13%) out of the 119 original articles for which the editorial process was completed were accepted. Our goal for the year 2010 is to make the journal available on the Internet for all those who are subscribers to the Rev Clin Esp as well as for internal medicine residents (for which they must be members of each regional society). Other objectives of the editorial team are to edit the E-cases, for the journal to be a continuing education tool and that the coordinators of the work groups develop a monographic number at least once every two years. These actions aim to increase the impact factor and the quality of the Rev Clin Esp, official publication of the Spanish Society of Internal Medicine and of Spanish-speaking internal medicine physicians.

Informe de los editores: 2009 / 2009 Report from the editors

Los editores de Revista Clínica Española (Rev Clin Esp) presentan las líneas de su actuación editorial en el último año. Hemos actualizado el diseño de la revista, sus contenidos (secciones) y el procedimiento editorial, que ha sido informatizado. Desde noviembre de 2008 hasta octubre de 2009 hemos gestionado 467 manuscritos y se ha adoptado una decisión editorial para 402. Han sido aceptados 92 manuscritos (23%). De 119 originales con proceso editorial concluido, se han aceptado 15 (13%). Para el año 2010 pretendemos que todos los suscriptores de Rev Clin Esp reciban la revista a través de Internet, al igual que los residentes de Medicina Interna (para lo cual deben ser miembros de cada sociedad autonómica). Otros objetivos del equipo editorial son la edición de e-comunicaciones clínicas, que la revista sea un instrumento de formación continuada y que los coordinadores de los grupos de trabajo promuevan un número monográfico al menos cada dos años. Estas acciones pretenden incrementar el factor impacto y la calidad de Rev Clin Esp, órgano de expresión de la Sociedad Española de Medicina Interna(AU)

The editors of the Rev Clin Esp present the editorial course of action of the journal over the past year. We have up-dated the design of the journal, its contents (sections) and computerized the editorial process. We processed 467 manuscripts and made an editorial decision on 402 of them between November 2008 and October 2009. A total of 92 manuscripts (23%) were accepted. Fifteen (13%) out of the 119 original articles for which the editorial process was completed were accepted. Our goal for the year 2010 is to make the journal available on the Internet for all those who are subscribers to the Rev Clin Esp as well as for internal medicine residents (for which they must be members of each regional society). Other objectives of the editorial team are to edit the E-cases, for the journal to be a continuing education tool and that the coordinators of the work groups develop a monographic number at least once every two years. These actions aim to increase the impact factor and the quality of the Rev Clin Esp, official publication of the Spanish Society of Internal Medicine and of Spanish-speaking internal medicine physicians(AU)